What are base editing and prime editing, and how do they differ from classic CRISPR-Cas9 knockout strategies?

What are base editing and prime editing, and how do they differ from classic CRISPR-Cas9 knockout strategies?

• A. Base editing converts C to T or A to G without DSBs using deaminases fused to Cas9 nickase; prime editing uses Cas9 nickase and reverse transcriptase with a pegRNA to write precise edits.
• B. Base editing creates double-strand breaks.
• C. Prime editing deletes large genomic regions.
• D. Classic CRISPR-Cas9 knockout edits are base changes.

Answer: (A)