Which statement best describes how epigenetic marks influence X chromosome inactivation and imprinting?

Which statement best describes how epigenetic marks influence X chromosome inactivation and imprinting?

• A. XIST coats both X chromosomes and initiates silencing across both.
• B. Imprinting silences both paternal and maternal alleles equally.
• C. XIST lncRNA coats one X chromosome to initiate silencing; DNA methylation and histone modifications reinforce silencing; imprinting relies on parent-specific DNA methylation to silence an allele.
• D. X-inactivation requires rapid RNA polymerase II turnover and imprinting relies on RNA editing.

Answer: (C)